Helicase Mechanisms During Homologous Recombination inSaccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
Multifaceted role of the Saccharomyces cerevisiae Srs2 helicase in homologous recombination regulation.
Homologous recombination (HR) is a major pathway for the elimination of DNA DSBs (double-strand breaks) induced by high-energy radiation and chemicals, or that arise due to endogenous damage and stalled DNA replication forks. If not processed properly, DSBs can lead to cell death, chromosome aberrations and tumorigenesis. Even though HR is important for genome maintenance, it can also interfere...
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Haploid Saccharomyces can change mating type through HO-endonuclease cleavage of an expressor locus, MAT, followed by gene conversion using one of two repository loci, HML or HMR, as donor. The mating type of a cell dictates which repository locus is used as donor, with a cells using HML and alpha cells using HMR. This preference is established in part by RE, a locus on the left arm of chromoso...
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Adenoviruses are used extensively to deliver genes into mammalian cells, particularly where there is a requirement for high-level expression of transgene products in cultured cells, or for use as recombinant viral vaccines or in gene therapy. In spite of their usefulness, the construction of adenoviral vectors (AdV) is a cumbersome and lengthy process that is not readily amenable to the generat...
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ژورنال
عنوان ژورنال: Annual Review of Biophysics
سال: 2019
ISSN: 1936-122X,1936-1238
DOI: 10.1146/annurev-biophys-052118-115418